Facile entry to the tetracyclic 5-7-6-3 tigliane ring system.
نویسندگان
چکیده
[figure: see text] A tandem anionic 5-exo-dig cyclization/Claisen rearrangement sequence was used to effect a facile, "one-pot" conversion of an appropriately substituted 4-alkyn-1-ol to the tetracyclic carbon core structure of phorbol. The synthesis was conducted using readily available nonracemic starting materials to provide the target structure as a single enantiomer in high chemical yield.
منابع مشابه
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عنوان ژورنال:
- Organic letters
دوره 3 1 شماره
صفحات -
تاریخ انتشار 2001